Brain Health: Omega-3

Author: Herbalife Nutrition
Angle shot of Omega-3 capsules and Omega-3-rich foods on a white wood surface

The brain is the most significant and complex organ of the entire human body. A healthy brain can perform all the mental processes that are collectively known as cognition, intuition, judgment, language, memory and the ability to learn (1). Throughout our lifespan, the brain helps to make sense of the world, oversee daily operations and life itself.

Omega-3 fatty acids, and in particular docosahexaenoic acid (DHA), support the normal functioning of the brain if taken consistently at amounts of 250 mg daily (2, 3).

DHA is mostly deposited in the brain (4, 5) where it forms part of our brain cell membranes (6) and plays a key role in several important processes (7-9). It has also been shown that DHA may be helpful in controlling pain (10-12) whilst recent science reports indicate that DHA can prevent brain cells from dying  (13, 14).

Studies show that low levels of DHA in the body can be associated with a higher risk of brain disorders (5, 7, 15, 16). Brain aging as well as brain disorders cause the loss of neurons (or brain cells) (17). The clever and complex human brain can create new brain cells through a process called neurogenesis (18,19), which occurs most intensively during foetal life (20). It is still present in adults, but at a slower rate and with less efficiency (21,22). Omega 3 fatty acids, especially DHA, can promote the phenomenon of neurogenesis in the brain (23, 24). DHA may also have a protective effect on brain cells, as well as promoting communication between them (24,25).

Dietary DHA has a profound effect on the proper functioning of synaptic plasticity – a function in the brain that helps it to adapt and process new information and therefore supports learning and memory functions (6, 26, 27).

 In summary, DHA is essential in the proper functioning of a brain, but there is still some work to do to fully understand the mechanisms by which DHA effects on the above-mentioned processes in the brain.

To obtain the required amounts of DHA, adults are encouraged to eat 1 to 2 portions of oily fish per week (28-30). Despite this recommendation, most people do not eat oily fish on a regular basis. In this case, dietary supplements can be a practical and beneficial alternative, especially when you consider the environmental pollutants affecting oceans nowadays (28-31). Due to the purification processes that are applied to fish oil supplements, the risk of exposure to environmental toxins with fish consumption is greatly reduced – making them a sound option for busy lifestyles. 

 

References

  1. Derbyshire E. Brain Health across the Lifespan: A Systematic Review on the Role of Omega-3 Fatty Acid Supplements. Nutrients. 2018;10(8):1094.
  2. EFSA. Scientific Opinion on the substantiation of health claims related to docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA) and brain, eye and nerve development (ID 501, 513, 540), maintenance of normal brain function (ID 497, 501, 510, 513, 519, 521, 534, 540, 688, 1323, 1360, 4294), maintenance of normal vision (ID 508, 510, 513, 519, 529, 540, 688, 2905, 4294), maintenance of normal cardiac function (ID 510, 688, 1360), “maternal health; pregnancy and nursing” (ID 514), “to fulfil increased omega-3 fatty acids need during pregnancy” (ID 539), “skin and digestive tract epithelial cells maintenance” (ID 525), enhancement of mood (ID 536), “membranes cell structure” (ID 4295), “anti-inflammatory action” (ID 4688) and maintenance of normal blood LDL-cholesterol concentrations (ID 4719) pursuant to Article 13(1) of Regulation (EC) No 1924/2006. EFSA Journal. 2011;9(4):2078-n/a.
  3. EC. COMMISSION REGULATION (EU) No 432/2012 of 16 May 2012 establishing a list of permitted health claims made on foods, other than those referring to the reduction of disease risk and to children’s development and health. 2012.
  4. F OD, Carney S, Kennedy J, Hayes H, Pender N, Boland F, et al. Associations and effects of omega-3 polyunsaturated fatty acids on cognitive function and mood in healthy adults: a protocol for a systematic review of observational and interventional studies. BMJ Open. 2019;9(6):e027167.
  5. Lo Van A, Hachem M, Lagarde M, Bernoud-Hubac N. Omega-3 Docosahexaenoic Acid Is a Mediator of Fate-Decision of Adult Neural Stem Cells. Int J Mol Sci. 2019;20(17):4240.
  6. Aryal S, Hussain S, Drevon CA, Nagelhus E, Hvalby Ø, Jensen V, et al. Omega-3 fatty acids regulate plasticity in distinct hippocampal glutamatergic synapses. The European journal of neuroscience. 2019;49(1):40-50.
  7. Mallick R, Basak S, Duttaroy AK. Docosahexaenoic acid,22:6n-3: Its roles in the structure and function of the brain. Int J Dev Neurosci. 2019;79:21-31.
  8. Ghasemi Fard S, Wang F, Sinclair AJ, Elliott G, Turchini GM. How does high DHA fish oil affect health? A systematic review of evidence. Crit Rev Food Sci Nutr. 2019;59(11):1684-727.
  9. Ahmmed MK, Ahmmed F, Tian HS, Carne A, Bekhit AE. Marine omega-3 (n-3) phospholipids: A comprehensive review of their properties, sources, bioavailability, and relation to brain health. Comprehensive reviews in food science and food safety. 2020;19(1):64-123.
  10. Nakamoto K, Nishinaka T, Mankura M, Fujita-Hamabe W, Tokuyama S. Antinociceptive effects of docosahexaenoic acid against various pain stimuli in mice. Biological & pharmaceutical bulletin. 2010;33(6):1070-2.
  11. Nakamoto K, Tokuyama S. [The role of brain n-3 fatty acids-GPR40/FFAR1 signaling in pain]. Nihon yakurigaku zasshi Folia pharmacologica Japonica. 2018;151(1):21-6.
  12. Nakamoto K, Nishinaka T, Sato N, Mankura M, Koyama Y, Tokuyama S. [Antinociceptive effect of docosahexaenoic acid (DHA) through long fatty acid receptor G protein-coupled receptor 40 (GPR40)]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 2014;134(3):397-403.
  13. Xu F, Song Y, Guo A. Anti-Apoptotic Effects of Docosahexaenoic Acid in IL-1β-Induced Human Chondrosarcoma Cell Death through Involvement of the MAPK Signaling Pathway. Cytogenetic and genome research. 2019;158(1):17-24.
  14. Ajith TA. A Recent Update on the Effects of Omega-3 Fatty Acids in Alzheimer's Disease. Current clinical pharmacology. 2018;13(4):252-60.
  15. Dyall SC. Long-chain omega-3 fatty acids and the brain: a review of the independent and shared effects of EPA, DPA and DHA. Front Aging Neurosci. 2015;7:52.
  16. von Schacky C. Importance of EPA and DHA Blood Levels in Brain Structure and Function. Nutrients. 2021;13(4).
  17. Morrison JH, Hof PR. Life and death of neurons in the aging brain. Science. 1997;278(5337):412-9.
  18. Kumar A, Pareek V, Faiq MA, Ghosh SK, Kumari C. ADULT NEUROGENESIS IN HUMANS: A Review of Basic Concepts, History, Current Research, and Clinical Implications. Innov Clin Neurosci. 2019;16(5-6):30-7.
  19. Gage FH. Neurogenesis in the adult brain. J Neurosci. 2002;22(3):612-3.
  20. Georgieff MK, Brunette KE, Tran PV. Early life nutrition and neural plasticity. Development and Psychopathology. 2015;27(2):411-23.
  21. Kase Y, Shimazaki T, Okano H. Current understanding of adult neurogenesis in the mammalian brain: how does adult neurogenesis decrease with age? Inflammation and Regeneration. 2020;40(1):10.
  22. Encinas JM, Michurina TV, Peunova N, Park JH, Tordo J, Peterson DA, et al. Division-coupled astrocytic differentiation and age-related depletion of neural stem cells in the adult hippocampus. Cell Stem Cell. 2011;8(5):566-79.
  23. Dyall SC. The role of omega-3 fatty acids in adult hippocampal neurogenesis. OCL. 2011;18(5):242-5.
  24. Cao D, Kevala K, Kim J, Moon HS, Jun SB, Lovinger D, et al. Docosahexaenoic acid promotes hippocampal neuronal development and synaptic function. J Neurochem. 2009;111(2):510-21.
  25. Butt C, Salem N. Mechanisms of Docosahexaenoic Acid (DHA) in Neurodevelopment and Brain Protection. 2015. p. 207-38.
  26. Tao G, Luo Y, Xue Q, Li G, Tan Y, Xiao J, et al. Docosahexaenoic Acid Rescues Synaptogenesis Impairment and Long-Term Memory Deficits Caused by Postnatal Multiple Sevoflurane Exposures. Biomed Res Int. 2016;2016:4062579.
  27. Wu A, Ying Z, Gomez-Pinilla F. Docosahexaenoic acid dietary supplementation enhances the effects of exercise on synaptic plasticity and cognition. Neuroscience. 2008;155(3):751-9.
  28. EFSA. Scientific Opinion on Dietary Reference Values for fats, including saturated fatty acids, polyunsaturated fatty acids, monounsaturated fatty acids, trans fatty acids, and cholesterol. EFSA Journal 2010; 8(3):1461. [online] Available at: http://www.efsa.europa.eu/en/efsajournal/pub/1461.html [Accessed on June 11, 2021] 2010.
  29. Chilton FH, Dutta R, Reynolds LM, Sergeant S, Mathias RA, Seeds MC. Precision Nutrition and Omega-3 Polyunsaturated Fatty Acids: A Case for Personalized Supplementation Approaches for the Prevention and Management of Human Diseases. Nutrients. 2017;9(11):1165.
  30. Saini RK, Keum YS. Omega-3 and omega-6 polyunsaturated fatty acids: Dietary sources, metabolism, and significance - A review. Life sciences. 2018;203:255-67.
  31. Zárate R, el Jaber-Vazdekis N, Tejera N, Pérez JA, Rodríguez C. Significance of long chain polyunsaturated fatty acids in human health. Clinical and Translational Medicine. 2017;6:25.